Aralykyl (arylethynyl)aralkyl amines and their use as vasodilato

Details Aralykyl (arylethynyl)aralkyl amines and their use as vasodilato Aralykyl (arylethynyl)aralkyl amines and their use as vasodilato

1984-10-29

1987-04-28

Warren, Charles F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564346, 564355, 564360, 564361, 564363, 564364, 564365, 558422, C07C 8728

Patent

active

046616357

ABSTRACT:
Acetylenes of the formula (I): ##STR1## wherein Y, m, R.sup.1, R.sup.2 q, Alk, R.sup.3, n and R.sup.4 are as defined herein and Ar.sup.1 and Ar.sup.2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention.

REFERENCES:
patent: 3719712 (1973-03-01), Remy
"Antiarrhythmic Agents, 2-, 3- and 4-Substituted Benzylamines," David C. Remy, J. Md. Chem., 1975, vol. 18, No. 2, pp. 142-148.

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