Pyrimido[1,2-a ]benzimidazole derivatives

Details Pyrimido[1,2-a ]benzimidazole derivatives Pyrimido[1,2-a ]benzimidazole derivatives

1977-11-23

1979-09-11

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544247, 544250, 548306, C07D48704, C07D49114, A61K 31505

Patent

active

041675690

ABSTRACT:
The invention concerns 3,4-dihydropyrimido [1,2-a]benzimidazole derivatives bearing one or more substituents at positions 6, 7, 8 or 9; processes for their preparation and manufacture; and pharmaceutical compositions thereof. The compounds inhibit the aggregation of blood-platelets and may be used in vivo, in the treatment or prophylaxis of thrombosis or occlusive vascular disease, or in vitro, in helping to stabilize preparations of blood platelets. Representative compounds of the invention are 7- and 8- acetyl-3,4-dihydropyrimido[1,2-a]benzimidazol-2(1H)-one.

REFERENCES:
patent: 3468888 (1969-09-01), Chow
patent: 3988340 (1976-10-01), Partyka et al.
patent: 4109087 (1978-08-01), Denzel et al.
patent: 4109091 (1978-08-01), Denzel et al.
Chow et al., Chem. Abs. 78, 111242k (1973).

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