Process for preparing mitomycin analogs

Details Process for preparing mitomycin analogs Process for preparing mitomycin analogs

1988-02-25

1989-03-21

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

546271, 548336, 548422, C07D48714, H61K 3140

Patent

active

048144452

ABSTRACT:
The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group. Mitomycin A is an antibiotic of established utility, and the 7-O-substituted mitosane analogs thereof have similar utility.

REFERENCES:
patent: 4487769 (1984-12-01), Vyas et al.
patent: 4691023 (1987-09-01), Vyas et al.
patent: 4746746 (1988-05-01), Remers
Ukrain. Khim. Zhur., 18, 631-634 (1952) Chem. Abst., 49, 982 (1955).
Ukrain. Khim Zhur., 21, 496-498 (1955) Chem. Abst., 50, 5549 (1956).
Ukrain. Khim. Zhur., 21, 628-630 (1955) Chem. Abst., 50, 11270 (1956).
S. M. Sami, et al., J. Med. Chem., 27, 701-708 (1984).
Farmdoc No. 56227 Derwent Publications which abstracts Japanese published appl. No. 556073-085 Chem. Abst., 96 6569w (1982).

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