Inhibitor of ribonucleotide reductase

Details Inhibitor of ribonucleotide reductase Inhibitor of ribonucleotide reductase

1987-05-22

1989-03-21

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530327, 530328, 530330, 514 23, 514575, 4351723, C07K 706, C07K 708

Patent

active

048144320

ABSTRACT:
A series of peptides has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.

REFERENCES:
Dutia et al., "Specific Inhibition of Herpesvirus Ribonucleotide Reductose by Synthetic Peptides," Nature, vol. 321, pp. 439-441 (1986).
Cohen et al., "Specific Inhibition of Herpesvirus Ribone Cleotide Reductose by a Nonapeptide Derived from the Carboxy Tervavirus of Sub Unit 2" Nature, vol. 321, pp. 441-443 (1986).
Gaudreau et al., "Structure Activity Studies on Synthetic Peptides Inhibiting Herpes Simplex Virus Siborucleotide Reductose," J. Biol. Chem., vol. 262, #26, pp. 12413-12416 (1987).

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