Phlorethyl-.beta.-alanyl-secretine

Details Phlorethyl-.beta.-alanyl-secretine Phlorethyl-.beta.-alanyl-secretine

1977-06-17

1979-09-11

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, C07G 700, A61K 37100

Patent

active

041675088

ABSTRACT:
A radioiodinated phloretyl-.beta.-alanyl-secretin, its salts and its protected derivatives. A process for the manufacture of a radioiodinated phloretyl-.beta.-alanyl-secretin and/or a salt thereof which process involves reacting phloretyl-.beta.-alanyl-secretin and/or a salt thereof with radioactive iodine. Phloretyl-.alpha.-alanyl-secretin, its salts and its protected derivatives. A method for the determination of secretin in a sample, which involves; mixing the sample with a known amount of a radioiodinated phloretyl-.beta.-alanyl-secretin and an antibody specific for secretin; measuring the degree of binding of the labelled radioiodinated phloretyl-.beta.-alanyl-secretin; and determining the amount of secretin present in the sample by comparing the degree of binding with a standard curve which has been obtained by adding known amounts of secretin to a defined mixture of the radioiodinated phloretyl-.beta.-alanyl-secretin and the antibody and determining the degree of binding for this known amount of secretin.

REFERENCES:
patent: 3740385 (1973-06-01), Ondetti
patent: 3987014 (1976-10-01), Giducci et al.
Chem. Abs., vol. 79 (1973), 134106d.

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