Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1987-09-28
1989-03-21
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424449, 427171, A61F 1302
Patent
active
048141747
ABSTRACT:
The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier.
The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 .mu.m with a high-energy irradiation in a dose of 1-15 Mrad--preferably with electrone radiation--and thereafter stretched at 80.degree.-90.degree. C. to a thickness of 2-200 .mu.m.
The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.
REFERENCES:
patent: 4486193 (1984-12-01), Shaw et al.
patent: 4615699 (1986-10-01), Gale et al.
patent: 4650484 (1987-03-01), Shaw et al.
Barta Iren
Fekete Pal
Kovacs Gabor
Mahr Lajos
Pallos Laszlo
Dubno Herbert
Egis Gyogyszergyar
Horne L. R.
Muanyagipari Kutato Intezet
Myers Jonathan
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