Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-03-17
1995-09-05
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 5142278, 5142352, 514253, 514323, 514326, 5142305, 514417, 5142362, 5142358, 5142355, A61K 31535, A61K 3154
Patent
active
054479290
ABSTRACT:
Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases, such as, rheumatoid arthritis and ostecarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis, are described. Said compounds can be prepared either by hyclroxamidating a corresponding carboxylic acid or deprotecting a corresponding benzyloxycarbamoyl compound.
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Dayer, et al. Proc. Natl. Acad. Sci. USA(1976), 73,945.
Johnson-Wint. B. Anal. Biochem. (1980) 104, 175.
Handa, et al., Chemical Abstracts, vol. 108, (1988) No. 167,973e.
Broadhurst, et al. Chemical Abstracts, vol. 118, (1993) No. 169,601n.
Broadhurst Michael J.
Brown Paul A.
Johnson William H.
Lawton Geoffrey
Ciambrone Coletti Ellen
Gould George M.
Hoffmann-La Roche Inc.
Johnston George W.
Ramsuer Robert W.
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