Trifluoroalkylureido 3-heterocyclic thio methyl cephalosporins

Details Trifluoroalkylureido 3-heterocyclic thio methyl cephalosporins Trifluoroalkylureido 3-heterocyclic thio methyl cephalosporins

1976-04-09

1978-05-30

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

260453AR, 260453AL, 260455A, 260583GG, 424246, 544 26, 544 27, 544 24, 544 25, 544 30, 560 34, C07D50136

Patent

active

040924750

ABSTRACT:
Trifluoroalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.4 is hydrogen or lower alkyl; R.sub.5 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups are disclosed. These compounds are useful as antibacterial agents.

REFERENCES:
patent: 3708479 (1973-01-01), Welch et al.
patent: 3891629 (1975-06-01), Diassi et al.
patent: 3925368 (1975-12-01), Cooper et al.
patent: 3948905 (1976-04-01), DeMarinis et al.
Yale, Journal of Medicinal and Pharmaceutical Chemistry, (1959), vol. 1, No. 2, pp. 121-132.

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