Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1998-11-30
2000-10-17
Carlson, Karen Cochrane
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 13, 435 692, 435243, 930250, 536 235, C07K 100
Patent
active
061334227
ABSTRACT:
There is provided a thrombin inhibitor polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. The anti-thrombin polypeptide is used to treat various diseases where prevention of blood clotting is necessary and is of therapeutic value. The present invention also discloses a method of producing the anti-thrombin polypeptide and methods for its use as a pharmaceutical composition.
REFERENCES:
Coughlin, P.B. et al., Journal of Biol. Chem., 268(13) 9541-9547 (1993).
Coughlin, P.B. et al., Proc. Natl. Acad. Sci. U.S.A., 90:9417-9421 (1993).
Morgenstern, K.N. et al., Biochem., 33:3432-3441 (1994).
Adams Mark D.
Cao Liang
Fuldner Rebecca A.
Rosen Craig A.
Carlson Karen Cochrane
Human Genome Sciences Inc.
Schnizer Holly
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