Antiviral compounds and antihypertensive compounds

Details Antiviral compounds and antihypertensive compounds Antiviral compounds and antihypertensive compounds

1997-02-26

1999-08-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546155, A61K 3137, C07D21522

Patent

active

059425229

ABSTRACT:
Compounds useful as antihypertensive agents and useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: ##STR1## and their pharmaceutically acceptable salts and solvates. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Methods of treating a viral infection using compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating hypertension using compounds of Formula 1.0 wherein R is selected from the group consisting of H, halogen and --C(O)OR.sup.6 ; and R.sup.1 is selected from the group consisting of --OR.sup.14, --O(CH.sub.2).sub.a C(H).sub.3-i Z.sub.i and --O(CH.sub.2).sub.h N(R.sup.15).sub.2.

REFERENCES:
patent: 2646355 (1953-07-01), Zweifel et al.
patent: 2844594 (1958-07-01), Long et al.
patent: 3008969 (1961-11-01), Pretka
patent: 3025299 (1962-03-01), Pfister et al.
patent: 3141893 (1964-07-01), Pfister et al.
patent: 3275658 (1966-09-01), Lednicer
patent: 3449335 (1969-06-01), Copeland
patent: 3515721 (1970-06-01), Ritter et al.
patent: 3715360 (1973-02-01), Gaeng et al.
patent: 3960868 (1976-06-01), Ferrini et al.
patent: 4024275 (1977-05-01), Archer
patent: 4031099 (1977-06-01), Buckle et al.
patent: 4066651 (1978-01-01), Brittain et al.
patent: 4079066 (1978-03-01), Gardner
patent: 4107310 (1978-08-01), Allais et al.
patent: 4124587 (1978-11-01), Hardtmann
patent: 4138490 (1979-02-01), Brittain et al.
patent: 4168312 (1979-09-01), Schacht et al.
patent: 4187309 (1980-02-01), Hardtmann
patent: 4187310 (1980-02-01), Brittain et al.
patent: 4190659 (1980-02-01), Hardtmann
patent: 4218448 (1980-08-01), Aldrich et al.
patent: 4251659 (1981-02-01), Aldrich et al.
patent: 4271303 (1981-06-01), Vamvakaris et al.
patent: 4281131 (1981-07-01), Hardtmann et al.
patent: 4284768 (1981-08-01), Santilli
patent: 4363811 (1982-12-01), Evans et al.
patent: 4526894 (1985-07-01), Enomoto et al.
patent: 4547511 (1985-10-01), Eriksoo et al.
patent: 4607039 (1986-08-01), Le Count et al.
patent: 4710507 (1987-12-01), Campbell et al.
patent: 4902693 (1990-02-01), Blythin et al.
patent: 4954518 (1990-09-01), Takano et al.
patent: 4963655 (1990-10-01), Kinder et al.
patent: 5064756 (1991-11-01), Carr et al.
patent: 5175151 (1992-12-01), Afonso et al.
patent: 5179093 (1993-01-01), Afonso et al.
patent: 5179107 (1993-01-01), Afonso et al.
patent: 5190956 (1993-03-01), Afonso et al.
patent: 5250547 (1993-10-01), Lochead et al.
patent: 5378694 (1995-01-01), Afonso et al.
patent: 5382572 (1995-01-01), Afonso et al.
patent: 5412104 (1995-05-01), Afonso et al.
patent: 5614532 (1997-03-01), Caruna
patent: 5696241 (1997-12-01), de Crous
Knierzinger et al., J. Heterocyclic Chem. 17, pp. 225-229, (1980).
Primafiore, Chem. Abstr vol. 88 entry 3769 (1976).
Primafiore et al, Atti Accad. Sci. 1st Bologna CI Sci Fis Rend 3(2), 95-98 (1976).
CA, vol. 114, 1991, Srivasta et al entry 143242P.
CA, vol. 86, 1977, Minker et al, 26053v.
J. Chem. Soc. 438-455 (1964) Clark and Gundon.
CA 88(5): 36830b (1978).
Yoshizaki et al., CA, vol. 113: 211864z (1990).
Schaefer et al., CA, vol. 109: 170249z (1988).
Derwent Abstract No. 81-35421D/198120 for J90005-752-B; published Feb. 1990.
Derwent Abstract No. 82-12633E/198207 for J89035-827-B; published Jul. 1989.
Primafiore et al., Atti. Accad. Sci. 1st Bologna CL Sci Fis Rend 3(2), 95-98 (1976) (CA 88(5)): 37696Z attached).
J. Chem. Soc. Perkin Trans., vol. 9 Sept., 1989, Brownsart et al., 1679-1686.
J. Chem. Soc. Perkin; vol. 5 May, 1989, Gaston et al., 905-908.
J. Med Chem. 1985, 28, 748-752 (Diana et al.).
CA 114: 143242P (1991) (Srivastava et al.).
CA 86:26053v (1977) (Minker et al.).
Briet et al., Chem. Abstract vol. 87, entry 184369c (1977).

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