Human interleukin-3 (IL-3) variant fusion proteins

Details Human interleukin-3 (IL-3) variant fusion proteins Human interleukin-3 (IL-3) variant fusion proteins

1995-06-06

2000-10-17

Fitzgerald, David L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 697, 536 234, 536 2351, 530351, 424 852, C12N 1524, C07K 1454, A61K 3820

Patent

active

061329916

ABSTRACT:
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.

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