Methods and compositions for multiple gene transfer into bone ce

Details Methods and compositions for multiple gene transfer into bone ce Methods and compositions for multiple gene transfer into bone ce

1994-09-30

1999-08-24

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 691, 4353201, 435325, 435455, 435458, 424 9321, A01N 4304

Patent

active

059424966

ABSTRACT:
Disclosed are methods, compositions, kits and devices for use in transferring nucleic acids into bone cells in situ and/or for stimulating bone progenitor cells. Type II collagen and, particularly, osteotropic genes, are shown to stimulate bone progenitor cells and to promote bone growth, repair and regeneration in vivo. Gene transfer protocols are disclosed for use in transferring various nucleic acid materials into bone, as may be used in treating various bone-related diseases and defects including fractures, osteoporosis, osteogenesis imperfecta and in connection with bone implants.

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