Process for preparing 3-isoxazolylurea derivatives

Details Process for preparing 3-isoxazolylurea derivatives Process for preparing 3-isoxazolylurea derivatives

1977-11-16

1980-07-15

Wheeler, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544137, 544367, 546209, C07D26114

Patent

active

042129818

ABSTRACT:
3-Isoxazolylurea derivatives of the formula: ##STR1## (wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl, or C.sub.6 -C.sub.8 aryl; R.sup.1 represents hydrogen or C.sub.1 -C.sub.6 alkyl; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.6 -C.sub.8 aralkyl, or C.sub.6 -C.sub.8 aryl; or ##STR2## represents pyrrolidino, piperidino, morpholino, or 4-alkylpiperazino; X represents hydrogen or halogen; or R and X may optionally form C.sub.3 -C.sub.5 alkylene), are prepared by reacting a carboxamide of the formula: ##STR3## (wherein R and X each is as defined above) with an amine of the formula:

REFERENCES:
patent: 3073839 (1963-01-01), Kano et al.
March, "Advanced Org. Chem." (1968), pp. 816-817.
Morrison et al., "Org. Chem." (1966), p. 927.
March, "Advanced Organic Chemistry," (1968) pp. 236-241.
Fieser, et al., "Reagents for Org. Syn." (1967), pp. 296-298, 310-311.

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