Preparation of cyclopentane-1,1-diacetic acid and intermediate

Details Preparation of cyclopentane-1,1-diacetic acid and intermediate Preparation of cyclopentane-1,1-diacetic acid and intermediate

1979-08-01

1980-07-15

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562503, C07D21158

Patent

active

042129737

ABSTRACT:
Disclosed is a process comprising reacting the reaction product of cyclopentanone and methyl cyanoacetate with cyanoacetamide and/or the reaction product of cyclopentanone and cyanoacetamide with methyl cyanoacetate, in the presence of a basic catalyst, to give the intermediate .beta.,.beta.-tetramethylene-.alpha.,.alpha.'-dicyanoglutarim ide, or its salt. In the process, the said reaction products may be formed together in the same reaction system, and the said intermediate preparation preferably is carried out between about 10.degree. C. and about 50.degree. C., in a polar, aprotic solvent, and in the presence of a basic catalyst, e.g., such as triethylamine. The intermediate may then be hydrolyzed to the cyclopentane-1,1-diacetic acid.

REFERENCES:
Benica and Wilson "J. Am. Pharm. Assn." vol. 39, pp. 451-454 (1950).

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