Process for manufacturing cephalosporin esters

Details Process for manufacturing cephalosporin esters Process for manufacturing cephalosporin esters

1985-11-07

1987-12-29

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514209, 514228, C07D50118, A61K 31545

Patent

active

047162279

ABSTRACT:
Cephalosporin esters of the formula ##STR1## wherein R.sup.2 is hydrogen or acyl and R.sup.1 is a group which is readily removable by hydrolysis,
and pharmaceutically acceptable acid addition salts of basic compounds of formula I in which R.sup.2 is an acyl group, may be prepared by reacting 7-amino-3-methyl-3-cephem-4-carboxylic acid (7-ADCA) in a partially chlorinated lower alkane with a bicyclic amidine of the formula ##STR2## wherein n is the integer 3, 4 or 5, and a halide of the formula

REFERENCES:
patent: 4405782 (1983-09-01), Palomo-Coll et al.
Oediger et al., Synthesis, Nov. 1982, pp. 591-598.

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