Novel polypeptide having an anti-tumor activity and a method of

Details Novel polypeptide having an anti-tumor activity and a method of Novel polypeptide having an anti-tumor activity and a method of

1987-11-20

1990-08-14

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1300

Patent

active

049488759

ABSTRACT:
Disclosed is a human TNF derivative with a reduced tendency to cause adverse side effects that is obtained by replacing the 31st and 32nd arginine residues from the N-terminal of the amino acid sequence of human TNF, which has a potential for causing serious adverse effects, with asparagine residue and threoine residue, respectively, as well as a method of preparing the same utilizing recombinant DNA technology.

REFERENCES:
patent: 4677063 (1987-06-01), Mark et al.
Pennica et al., Nature, vol. 312, pp. 724-729, (1984).
Beutler et al., Nature, vol. 316, pp. 552-554, (1985).
Beutler et al., Nature, vol. 320, pp. 584-588, (1986).
Old, Science, vol. 230, pp. 630-632, (1985).

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