Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-08-10
1980-07-15
Lee, Mary C.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424274, C07D48704
Patent
active
042128072
ABSTRACT:
Disclosed is a process for chemically cleaving the acyl group from N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxyl ic acids which proceeds via an imino chloride intermediate. The acylated substrate and the deacylated product are antibiotics.
REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
Okamura et al., J. Antibiotics, vol. 31, No. 5, pp. 480-482 (1978).
Arno James A.
Lee Mary C.
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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