Saturated fatty acid amides as inhibitors of acyl-CoA:cholestero

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514506, 546337, 546336, 544302, 544311, 544316, 544319, 544335, 564189, 564190, 564204, 564219, A61K 3144, A61K 3116, A61K 31165, C07D21336, C07C10319

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047161752

ABSTRACT:
Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.

REFERENCES:
patent: 4410697 (1983-10-01), Torok et al.
Chem. Abstracts; Boyles et al., vol. 94, No. 121134w (1981).
Chem. Abstracts; Volkenshtein et al., vol. 104, 199590m (1986).

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