Histamine H1 antagonists

Details Histamine H1 antagonists Histamine H1 antagonists

1986-10-21

1987-12-29

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544269, 544272, 544267, C07D47308, A61K 3152

Patent

active

047161663

ABSTRACT:
Histamine H.sub.1 -receptor antagonists of the formula: ##STR1## where R.sup.1 is hydrogen or alkyl; one of R.sub.2 and R.sup.3 is alkyl and the other is ##STR2## where R.sup.4 is pyridin-2-yl, pyridin-4-yl, thienyl, or phenyl, any of which is optionally substituted by a halo, alkyl of 1 to 6 carbon atoms, nitro, trifluoromethyl, hydroxy or alkoxy of 1 to 6 carbon atoms substituent; and R.sup.5 is pyridin-2-yl, pyridin-4-yl or phenyl, any of which is optionally substituted by a halo, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, nitro or trifluoromethyl substituent.

REFERENCES:
patent: 4426383 (1984-01-01), Sugimoto et al.
patent: 4564617 (1986-01-01), Sugimoto et al.
patent: 4603204 (1986-07-01), Thiele et al.

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