Conversion of acid S, produced by the organism Polyangium cellul

Details Conversion of acid S, produced by the organism Polyangium cellul Conversion of acid S, produced by the organism Polyangium cellul

Filed on

1978-07-14

Date issued

1980-07-15

Examiner

Shaver, Paul F.

Patent Class

Harness for working animal

Other Related Categories

542447, 424115, 424121, 424122, C09B 2300

Type

Patent

Status

active

Patent number

RE0303399

Description

ABSTRACT:
A process for the conversion of the major antifungal antibiotic, acid S (ATCC No. 25532) isolated from the fermentation of Polyangium cellulosum var. fulvum into the minor antibiotic, acid F, from the same fermentation is described wherein acid S is methylated with diazomethane to provide acid S methyl ester which is then oxidized with silver carbonate on celite to obtain the corresponding keto ester S, which is subsequently reduced with sodium borohydride to give a mixture of acid S methyl ester and acid F methyl ester. These esters are readily separated by preparative thin layer chromatography and the acid F methyl ester is hydrolyzed with sodium hydroxide solution to provide acid F.

REFERENCES:
patent: 3651216 (1972-03-01), Ringel et al.
patent: 3804948 (1974-04-01), Strandtmann et al.
patent: 4001398 (1977-01-01), Connor et al.
patent: 4009261 (1977-02-01), Connor et al.
patent: 4016257 (1977-04-01), Connor et al.

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