Cephem compounds, and use

Details Cephem compounds, and use Cephem compounds, and use

1989-03-15

1990-11-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540225, 540227, C07D50136, A61K 31545

Patent

active

049719637

ABSTRACT:
An antibacterial agent is provided which is a cephem compound of the formula: ##STR1## wherein R.sup.1 is an acyl group; R.sup.2 is a carboxy group which may be esterified; R.sup.3 is a hydrogen atom, a lower alkyl group or cyano group; R.sup.4 is a hydrogen atom or a lower alkyl group, or R.sup.4 together with R.sup.3 is a methylene chain having 2 or 3 carbon atoms; R.sup.5 is a hydrogen atom or a lower alkyl group; A is an optionally substituted bivalent aromatic heterocyclic group which is bonded to a ring-constituting carbon atom with the adjacent sulfur atom; Y is a binding arm, sulfur or oxygen atom, --NH--, --CONH-- or --NHCO--; Z is a binding bond or --NH--; m is an integer of 0 to 4 and n is an integer of 0 to 6, or a pharmacologically acceptable salt thereof.

REFERENCES:
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4264595 (1981-04-01), Numata et al.
patent: 4331666 (1982-05-01), Nannini et al.
patent: 4510138 (1985-04-01), Ochiai et al.
patent: 4681877 (1987-07-01), Muto et al.
patent: 4788185 (1988-11-01), Miyake et al.

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