Protection of human and animal cells during surgical trauma

Details Protection of human and animal cells during surgical trauma Protection of human and animal cells during surgical trauma

1988-03-02

1990-11-20

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 31715

Patent

active

049719556

ABSTRACT:
The cells of the coverings and linings of internal human and animal tissues, organs and body cavities subject to trauma, such as surgery, may be protected against exfoliation or destruction by the topical application or injection of effective amounts of chondroitin sulfate prior to or during the trauma. Preferably, the chondroitin sulfate is used in physiological solutions in concentrations of about 40 to 55 weight percent, and may be used as a surgical irrigating solution. Intraarticular injection of such chrondroitin sulfate solutions into human and animal joints having degenerative joint conditions protects the joint cells, reduces aseptic inflammation and/or prevents further dengeration of cartilage tissue. Solutions for preserving human and animal cells and tissues in vitro for later in vivo use have extended storage life when chondroitin sulfate is added to such storage solutions in effective amounts such as about 1 to 20 weight percent of the storage solution.

REFERENCES:
patent: 1950100 (1934-03-01), Crandall
patent: 4105760 (1978-08-01), Szejtli et al.
patent: 4640912 (1987-02-01), Hausman
Webster's II New Riverside Dictionary, p. 562 (Boston; Houghton Mifflin Company, 1984).
Morii et al.--Chem. Abst. vol. 72 (1970) p. 35780t.
Cheng--Chem. Abst. vol. 103 (1985) p. 189,544q.
Morrison et al.--Chem. Abst. vol. 63 (1965) p. 12090g.
Wolarsky et al.--Chem. Abst. vol. 63 (1965) p. 18766e.

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