Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof

Details Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof

1975-02-27

1979-12-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544247, 544248, 544251, 544286, 424250, A61K 31395, C07D48704

Patent

active

041795601

ABSTRACT:
Imidazo- and pyrimido[2,1-b]quinazolines of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, nitro, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, or R.sub.1 and R.sub.2 may together represent methylenedioxy; R.sub.3 is hydrogen, C.sub.1-4 alkyl, phenyl or substituted phenyl of the formula, ##STR2## (wherein R is halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy); R.sub.4 is hydrogen, C.sub.1-4 alkyl or aralkyl; and A is C.sub.2-3 alkylene wich may be optionally substituted by one or two C.sub.1-2 alkyl radicals, and pharmaceutically acceptable acid addition salts thereof, are prepared by reacting a compound of the formula, ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined above; and X is oxygen or sulfur, with a halogenating agent at a temperature of about 30.degree. C. to about 180.degree. C. In the above imidaxo- and pyrimido[2,1-b]quinazolines, those having C.sub.1-4 alkyl, or ##STR4## as R.sub.3 are novel compounds and show antidepressant and/or antihypertensive activities.

REFERENCES:
patent: 3621025 (1971-11-01), Jen et al.
patent: 3887559 (1975-06-01), Hardtmann

Affiliated with

Also associated with

Rating

Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-453988