Substituted acyl derivatives of chair form of octahydro-1H-indol

Details Substituted acyl derivatives of chair form of octahydro-1H-indol Substituted acyl derivatives of chair form of octahydro-1H-indol

1981-06-29

1984-01-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548494, 548504, 548510, C07D20918, C07D20920, A61K 31405

Patent

active

044253559

ABSTRACT:
Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acid and the pharmaceutically acceptable salts thereof are produced by acylating a suitably substituted octahydro-1H-indole with a suitably activated substituted carboxylic acid and when desired hydrolyzing the resulting product. The compounds of the invention, their salts and pharmaceutical compositions thereof are useful as antihypertensive agents.

REFERENCES:
patent: 3501497 (1970-03-01), Bell
patent: 4251444 (1981-02-01), Freed et al.
patent: 4303583 (1981-12-01), Kim et al.
Wollenweber, et al.; "Compounds Active on Blood Pressure", Chem Abst, 57, 16561(f) (1962).
Enenkel, et al.; "Octahydro Indole Deriv. . . . ," Chem Abst, 60: 1706(c) (1963).
Fruton, et al.; General Biochemistry II (1958).

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