Anti-diarrheal 2-substituted quinuclidines

Details Anti-diarrheal 2-substituted quinuclidines Anti-diarrheal 2-substituted quinuclidines

1979-04-30

1980-05-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546133, A61K 31445, C07D45302

Patent

active

042039908

ABSTRACT:
The present invention provides 2-substituted quinuclidines of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R is phenyl, halogen-substituted phenyl, lower alkyl-substituted phenyl, pyridyl or 5-methyl-1,3,4-oxadiazol-2-yl.
These quinuclidine compounds are useful as anti-diarrheal agents.

REFERENCES:
patent: 3917615 (1975-11-01), Adelstein
patent: 3998832 (1976-12-01), Adelstein et al.
patent: 4013667 (1977-03-01), Yen
patent: 4017491 (1977-04-01), Adelstein
patent: 4086234 (1978-04-01), Dryden et al.
patent: 4125531 (1978-11-01), Yen
Adelstein, G., et al., J. Med. Chem., 19(10), 1221-1225 (1976).
Martensson, Acta Chem. Scand. 19(3), 711 (1965).

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