Alkylation of aniline with a lactone in the presence of a base

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2603265FL, 549 63, C07D30732, C07D20726, C07D33336

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active

042039045

ABSTRACT:
A process for producing a lactone-substituted aniline wherein a 3-halo-tetrahydro-2-oxofuran is reacted with an aniline in the presence of water and a base at a temperature between 80.degree. and 160.degree. C. and wherein the base is added at a sufficiently slow rate so that the pH does not exceed about 7.5.

REFERENCES:
patent: 3002976 (1961-10-01), Janssen
patent: 3097206 (1963-07-01), Zirkle
patent: 3714153 (1973-01-01), Martel et al.
patent: 3786097 (1974-01-01), Karrer
patent: 3833607 (1974-09-01), Enders et al.
patent: 3914311 (1975-10-01), Coulson
patent: 3933860 (1976-01-01), Chan

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