Process for preparing alpha-(3-benzylphenyl) propionic acid deri

Details Process for preparing alpha-(3-benzylphenyl) propionic acid deri Process for preparing alpha-(3-benzylphenyl) propionic acid deri

1990-03-23

1991-03-12

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562491, 562406, 568429, 585320, 585323, C07C 6976

Patent

active

049994506

ABSTRACT:
A process for preparing .alpha.-(3-benzylphenyl)-propionic acid or its derivative, a precursor of ketoprofen (trade name), which comprises dehydrogenating a by-product oil fraction formed in the production of ethylbenzene using synthetic zeolite as an alkylating catalyst, and carbonylating the product with carbon monoxide or the like. This precursor can be easily converted into ketoprofen, a useful medicine as an anti-inflammatory agent.

REFERENCES:
patent: 3641074 (1972-02-01), Fenton
patent: 3641127 (1972-02-01), Farge et al.
patent: 4423021 (1983-12-01), Rollmann et al.
patent: 4536595 (1985-08-01), Gardano et al.
patent: 4731483 (1988-03-01), Shimizu et al.

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