Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1995-04-17
1997-03-11
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
514682, 568308, 568325, A61K 3112, C07C 49213
Patent
active
056101970
ABSTRACT:
This invention relates to benzyl and naphthalenylmethyl thiophenones and cyclopentenones, some of which are novel, which have oral antihyperglycemic activity in diabetic mice, a genetic animal model of non-insulin dependent diabetes mellitus. These compounds are represented by the formula ##STR1## wherein: R.sup.2 and R.sup.3 are independently selected from hydrogen, C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy, thio-C.sub.1-6 alkyl, or trifluoromethyl or R.sup.2 together with R.sup.3 forms a benzo ring fused to the phenyl ring and optionally substituted with one or two substituents independently selected from C.sub.1-6 alkyl, halogen, C.sub.1-6 alkoxy, thio-C.sub.1-6 alkyl, or trifluoromethyl;
REFERENCES:
patent: 4283348 (1981-08-01), Wheeler
patent: 4436666 (1984-03-01), Wheeler
patent: 4665174 (1987-05-01), Minai
patent: 4897405 (1990-01-01), Alessi
Tolstikov et al., Zh. Org. Khim., 27(1), 83-90 (CA115:135732d) (1991).
Stachel and Fendl, Arch. Pharm., 321(7), 439-40 (CA 109:230684z) (1988).
Strunz et al., Can. J. Chem., vol. 60, No. 5, 1982, 572-573.
Leir, J. Org. Chem., vol. 35, No. 10, 1970, 3203-3205.
Boswell, Jr. R. F.
Cebulak Mary C.
Dees Jos,e G.
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