N-acylpiperidine tachykinin antagonists

Details N-acylpiperidine tachykinin antagonists N-acylpiperidine tachykinin antagonists

1994-02-17

1997-03-11

Owens, Amelia A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514325, 546226, A61K 31445, C07D21106

Patent

active

056101651

ABSTRACT:
N-Acylpiperidines of general structure ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.

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Lowe, et al., "The Discovery of (2S,3S)-cis)-2-(Diphenylmethyl)-N-[(2-methoxphenyl) methyl]-2-azabicyclo [2.2.2.]-octan-3-amine . . .", J. Med. Chem. 35, pp. 2591-2600 (1992).
Lowe, et al., "Substance P Antagonists", Drug News Perspect., 5(4), pp. 223-227, (1992).
Mills, et al., "1,4-Diacylpiperazine-2-(S)-[(N-Aminoalkyl)Carboxamides], as Novel, . . .", Bioorganic & Medicinal Chemistry Letters, 3(12), pp. 2707-2712, (1993).

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