Virus-safe blood coagulation factor XIII preparation

Details Virus-safe blood coagulation factor XIII preparation Virus-safe blood coagulation factor XIII preparation

1994-07-26

1997-03-11

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 530380, 530381, 530427, 530830, A61K 3836, A61K 3516, C07K 14745, C07K 1447

Patent

active

056101473

ABSTRACT:
The present invention relates to a virus-safe blood coagulation factor XIII preparation, which is obtained by heating an aqueous solution containing the blood coagulation factor XIII having a specific activity of at least 2 U/mg of total protein, wherein the solution containing less than 10% of known stabilizers selected from the group consisting of sugars, polyols, amino acids, peptides and carboxylic acids, as well as less than 0.5 mol ammonium sulfate per liter, wherein the heating is effected for a period of time sufficient to inactivate infectious agents, preferably for a period of time of from 30 min to 100 h.

REFERENCES:
patent: 4816251 (1989-03-01), Seelich
patent: 5151499 (1992-09-01), Kameyama et al.
patent: 5410022 (1995-04-01), Eibl
Mauler et al., "Inaktivierung von Viren in Faktor-XIII-Konzentrat durch Erhitzen in Losung", Arzneim.Forsch./Drug Res., 34, Table 2, (1984), pp. 1524-1527.
"Ad Hoc Working Party on Biotechnology/Pharmacy, Directive EC III/8115/89-EN of the Commission of the EC", pp. 1-15.
Method for heating blood coagulation factor XIII, Derwent Accession, No. 91-175118.

Affiliated with

Also associated with

Rating

Virus-safe blood coagulation factor XIII preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Virus-safe blood coagulation factor XIII preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Virus-safe blood coagulation factor XIII preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-443661