Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[

Details Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[ Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[

1988-11-04

1990-02-06

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546166, 546180, C07D45506, C07D21512

Patent

active

048989452

ABSTRACT:
A process for preparing 6,7-dihydro-9-fluoro-5,8-dimethyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carb oxylic acid, an antimicrobial, using 6-fluoro-2-methylquinoline as a starting material. A synthetic intermediate is also disclosed.

REFERENCES:
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patent: 4380543 (1983-04-01), Stern
patent: 4443447 (1984-04-01), Gerster et al.
patent: 4472405 (1984-09-01), Stern
patent: 4472407 (1984-09-01), Stern
patent: 4524148 (1985-06-01), Stern
patent: 4538003 (1985-08-01), Tam
March J. Adv. Org. Chem. pp. 410-412, 2nd Ed. (1977).
Morrison et al. Org. Chem. pp. 386-387, 3rd Ed (1972).
Kohei Tamao et al., Bulletin Chemical Society of Japan, 49, 1958-1969 (1976).
Bergstrom, et al., Tetrahedron Letters, 23, 4191-4194 (1982).

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