Antiprotozoal diamidines and bis-imidazoline

Details Antiprotozoal diamidines and bis-imidazoline Antiprotozoal diamidines and bis-imidazoline

1986-07-25

1988-03-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548350, A61K 31415

Patent

active

047329076

ABSTRACT:
Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and 2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole, are useful in the treatment of certain protozoal infections in mammals, particularly in cattle.

REFERENCES:
patent: 3652591 (1972-03-01), Dann
patent: 3689506 (1972-09-01), Dann
Steck et al., Experimental Parasitology, vol. 52, pp. 404-413, 1981.
Clercq et al., J. Med. Chem., vol. 23, pp. 787-795 (1980).
Das et al., [A], J. Med. Chem., vol. 20, pp. 531-536 (1977); [B], vol. 20, pp. 1219-1221 (1977); [C], vol. 23, pp. 578-581 (1980).
Dann et al., Ann., 1975, pp. 160-194.
Anne et al., Antimicrobial Agents and Chemotherapy, vol. 18, pp. 231-239 (1980).

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