Isoquinoline derivatives and their use as analgesics

Details Isoquinoline derivatives and their use as analgesics Isoquinoline derivatives and their use as analgesics

1989-02-17

1990-09-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142225, 5142268, 5142282, 5142352, 514290, 514298, 514309, 544 2, 544 5, 544 8, 544 55, 544 62, 544 96, 544128, 546 79, 546 93, 546108, 546111, 546143, 546144, 546145, 546146, 546147, A61K 3147, C07D

Patent

active

049545094

ABSTRACT:
A compound, or a solvate or salt thereof, of formula (I): ##STR1## in which: RCO is an acyl group in which the group R contains a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic ring and R.sub.1 R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl or C.sub.4 -12 cycloalkylalkyl groups or together form a C.sub.2-8 branched or linear polymethylene or C.sub.2-6 alkenylene group optionally substituted with a hetero-atom;

REFERENCES:
patent: 4232160 (1980-11-01), Schut et al.
patent: 4753952 (1988-06-01), Vecchietti et al.
patent: 4806547 (1989-02-01), Giardina et al.
"Chemical Abstracts", vol. 98, 1983, col. 98:89195m.
Jin, et al., "Chemical Abstracts", vol. 106, 1987, col. 106:4976c.
Giarding, et al., "Chemical Abstracts", vol. 108, 1988, col. 108:37666w.

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