Controlled absorption pharmaceutical composition

Details Controlled absorption pharmaceutical composition Controlled absorption pharmaceutical composition

1988-04-27

1990-02-06

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

427 3, 424459, 424460, 424473, 424490, 424497, 514965, A61K 916, A61K 952

Patent

active

048987379

ABSTRACT:
A sustained absorption propranolol-containing pellet for oral administration comprises a core of propranolol or a pharmaceutically acceptable salt thereof and an organic acid embedded in a polymeric material in a multi-layer arrangement and an outer membrane which permits release of the propranolol at a controlled rate in an aqueous medium. The pellet has a dissolution rate in vitro in an aqueous medium, which when measured in a basket assembly according to U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m., is not more than 15% of the total propranol after 2 hours of measurement in a buffer solution at pH 7.5. Not more than 30% of the total propranolol is released after a total of 4 hours of measurement and not more than 63% of the total propranolol is released after a total of 6 hours.

REFERENCES:
patent: 4138475 (1979-02-01), McAinsh et al.
patent: 4150110 (1979-04-01), Yoshida et al.
patent: 4248856 (1981-02-01), Guley et al.
patent: 4248857 (1981-02-01), DeNeale et al.
patent: 4248858 (1981-02-01), Guley et al.
patent: 4309404 (1982-01-01), DeNeale et al.
patent: 4309406 (1982-01-01), Guley et al.

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