Process for producing enyne derivatives

Details Process for producing enyne derivatives Process for producing enyne derivatives

1992-11-12

1994-03-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 55, 549 58, 549 59, 549 60, 549 61, 549 64, 549 65, 549 74, 549 75, 556483, 558257, 560 34, 560 38, 560 61, 560 62, 560 65, C07C21102, C07D33358

Patent

active

052966127

ABSTRACT:
A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane epoxidase of Eumycetes and strong anti-cholesterol activities. The process comprises reacting a compound of the formula: ##STR1## wherein W is a halogen atom, with an acetylene derivative, in the presence of a palladium catalyst, to obtain a compound of the formula: ##STR2## and, if necessary, N-alkylating this compound.

REFERENCES:
patent: 4855086 (1989-08-01), Black et al.
D. Rudisill et al. Tetrhedron Letters, vol. 29, No. 13, 1988 Pergamon Press plc.
Bottinis et al. Chemical Abstracts, vol. 58, No. 6, Mar. 18, 1963, abstract No. 5493a.
H. Tilles Journal of the American Chemical Society, vol. 81, No. 3, Feb. 12, 1959 pp. 714-727.
Accounts of Chemical Research, "Palladium-Catalyzed Reactions of Organic Halides with Olefins", Richard F. Heck, 1979.
Accounts of Chemical Research, "Palladium-or Nickel-Catalyzed Cross Coupling". A New Selective Method for Carbon-Carbon Bond Formation, Ei-Ichi Negishi, 1982.
A Satz et al. J. Med. Chem., 1984, 27, 1539-1543, "Synthesis and Antifungal Activity of (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N--Methyl . . . ".
A Statz et al. Tetrahedron, vol. 41, No. 23, 1985 "Die Verwendun von Diisobutylaluminum hydrid zur Stereoselektiven Synthesis von . . . " pp. 1539-1543.
W. Granitzer et al. "Tetrahedron Letters, No. 34, Aug. 1979," Stereoselective Trans-Reduktion . . . pp. 3145-3147.
Geisler et al. Chemical Abstracts, vol. 63, No. 10, Nov. 8, 1965, abstract No. 12999(f).

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