Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-

Details Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'- Inhibition of the 5-lipoxygenase pathway utilizing certain 2,2'-

1987-11-10

1989-07-11

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 546256, 548337, A61K 31415, C07D40114

Patent

active

048472700

ABSTRACT:
Novel compounds, pharmaceutical compositions and a method of inhibiting the 5-lipoxygenase products in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a 2,2'-[1,2-ethanediylbis-(thio)]-bis-1H-imidazole or 2,2'-[1,3-propan-2-onediylbis-(thio)]bis-1H-imidazole, or a pharmaceutically acceptable salt thereof, to such animal.

REFERENCES:
patent: 4188397 (1980-02-01), Hill
patent: 4339583 (1982-07-01), Cross et al.
patent: 4728656 (1988-03-01), Bender et al.

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