Thiazolylbenzofuran derivatives and pharmaceutical composition c

Details Thiazolylbenzofuran derivatives and pharmaceutical composition c Thiazolylbenzofuran derivatives and pharmaceutical composition c

1992-08-12

1994-03-22

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514215, 514337, 514338, 514367, 540578, 546269, 546270, 546274, 548159, 548201, 548203, 548204, 548205, A61K 31425, C07D41704, C07D41714

Patent

active

052964957

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A, X and Y are as defined and pharmaceutically acceptable salts thereof; which have activities as leukotriene and Slow Reacting Substance of Anaphalaxis (SRS-a) antagonists or inhibitors, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or treatment of allergy or inflamation in human beings or animals.

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Chemical Abstracts, vol. 90, p. 603, 90:152062t, G. Sarodnick et al., "Heterocyclic Substituted Thiazoles as Thiabendazole Analogs", 1979.
J. Heterocycl. Chem., vol. 16, pp. 97-103, Jan. 1977, G. Vernin et al., "Homolytic Aromatic Substitution of Heterocyclic Compounds. Part XIII. Arylation and Heteroarylation of Coumarin and Benzo[b]furan Using Triazenes as the Source of Radicals. An Experimental and Theoretical Study (1)".
J. Med. Chem., vol. 33, pp. 1186-1194, 1990, R. D. Youssefyeh et al., "Development of a Novel Series of (2-Quinolinylmethoxy)phenyl-containing Compounds as High-Affinity Leukotriene Receptor Antagonists. 1. Initial Structure-Activity Relationships".

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