Fluorenyl substituted tyrosyl dipeptide amides which are useful

Details Fluorenyl substituted tyrosyl dipeptide amides which are useful Fluorenyl substituted tyrosyl dipeptide amides which are useful

1988-01-20

1989-07-11

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2609982, A61K 3702, C07K 712

Patent

active

048472417

ABSTRACT:
The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, --OCO.sub.2 lower alkyl, lower alkoxy, --O(CH.sub.2).sub.n --phenyl with the phenyl optionally substituted by halogen, --NO.sub.2, --CN, --NH.sub.2 or lower alkyl wherein n is 1 to 4; R.sup.2 and R.sup.3 represent lower alkyl, halogen, or lower alkoxy, or either one of R.sup.2 or R.sup.3 is hydrogen and the other is lower alkyl, lower alkoxy or halogen; R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 may be the same or different and represent hydrogen or lower alkyl; R.sup.10 is selected from the group consisting of

REFERENCES:
patent: 4127535 (1978-11-01), Coy et al.
patent: 4599325 (1986-07-01), Hansen, Jr. et al.

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