Direct fluorination of substituted pyridines

Details Direct fluorination of substituted pyridines Direct fluorination of substituted pyridines

1987-07-09

1988-11-22

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546298, 546303, 546314, 546315, 546340, 546345, C07D21372, C07D21324, C07D21304, C07D21330

Patent

active

047867337

ABSTRACT:
Substituted pyridine compounds particularly alkyl-substituted pyridines, are directly fluorinated to the corresponding 2-fluoro alkyl-substituted pyridines. Fluorine gas, preferably diluted with an inert gas, is passed into the substituted pyridine, preferably in a solvent, at a temperature of +25.degree. C. to -40.degree. C., preferably about -25.degree. C.

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patent: 4567274 (1986-01-01), Gatlin et al.
Boudakian, J. Heterocyclic Chem., 1967, 4, 381.
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MeBee, Ind. Eng. Chem., 1947, 39, 389.
Mosher, Heterocyclic Compounds, vol. I. ed. R. C.
Elderfield, Chapter 8, p. 509, John Wiley, 1950.
Meinert, H. Z. Chem., 3, Jg. (1965).

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