Synthetic antigens of sialic acid and derivatives thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 11, 536 172, 536 179, 536 182, 536 187, 536 22, 536 53, 536120, 530807, C07H 702, C07H 306, C07H 1518

Patent

active

050345168

ABSTRACT:
A compound X-Y wherein X comprises sialic acid, a sialic acid derivative or an oligosaccharide terminating in a sialic acid or sialic acid derivative if multibranched at the end of at least the largest branch, and, Y represents coupling means which allows an antibody to be raised to X when the compound is coupled to a carrier through the coupling means Y and the coupled compound used to raise said antibody. These compounds show utility in that they, and antibodies raised against these, can be used in detecting and diagnosing cancers.

REFERENCES:
patent: 4137401 (1979-01-01), Lemieux et al.
patent: 4238473 (1980-12-01), Lemieux et al.
patent: 4415733 (1983-11-01), Tayot
patent: 4557931 (1985-12-01), Irie et al.
patent: 4613589 (1986-09-01), Rosenbrook et al.
patent: 4767845 (1988-08-01), Lemieux et al.
patent: 4794176 (1988-12-01), Lemieux et al.
patent: 4797477 (1989-01-01), Yoshimura et al.
patent: 4851511 (1989-07-01), Hakomori et al.
Kosma, P. et al., Int. Carbohydrates Synp., Aug. 10-15, 1986.
Kochelkov, N. K., Pure and Appl. Chem., vol. 56(7), 923-938, (1984).
Chernyak, A. Y. et al., Carbohydrate Research, 128, 269-282 (1984).
Chernyak, A. Y. et al., Carbohydrate Research, 141, 199-212 (1985).
Roxova-Benkova, L. et al., Carbohydrate Research 122, 269-281 (1983).
Schamer, R., "Sialic Acids, Chemistry, Metabolism and Function", ed. Schamer, R., Springer-Verlag, Vienna (1982).
Feizi, T., Nature, 314, 53-57 (1985).
Steward, M. W. and Howard, C. R., Immunology Today, 8(2), 51-58 (1987).
Zanetti, M. et al., Immunology Today, 8 (1), 18-25 (1987).
Imura, H. et al., Computer Search Print Out.
Hakomori, S., Scientific American, May 1986, p. 47.
Frechet et al., J. Am. Chem. Soc. 93(2):492-496 (1971).
Keilich et al., Carb. Res. 40:255-262 (1975).
Lemieux et al., J. Am. Chem. Soc. 97(14):4076-4083 (1975).
Nudelman et al., J. Biol. Chem. 257(21):12752-12756 (1982).
Magnani et al., J. Biol. Chem. 257(23):14365-14369 (1982).
Young, Jr. et al., J. Biol. Chem. 258(8):4890-4894 (1983).
Fukushima et al., Cancer Res. 44:5279-5285 (1984).
Hansson et al., J. Biol. Chem. 260(16):9388-9392 (1985).
Shimizu et al., Carb. Res. 166:314-316 (1987).
Carbohydrate Research 149:59-64 (1986), Kelm et al.
Pure and Applied Chemistry 56(7):907-921 (1984), Schauer et al.
R. Schauer, Sialic Acids, Chemistry, Metabolism and Function, Springer-Verlag, Vienna (1982).
Pozsgay et al., J. Carbohydrate Chemistry 6(1):41-55 (1987).
Sato et al., Carbohydrate Research 167:197-210 (1987).
Roy et al., Carbohydrate Research 177:c1-c4 (1988).
Roy et al., J. Carbohydrate Chemistry 6(1):161-165 (1987), presented at the 13th Intnat'l. Carbohyd. Symposium, Aug. 10-15, 1986.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Synthetic antigens of sialic acid and derivatives thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthetic antigens of sialic acid and derivatives thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic antigens of sialic acid and derivatives thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-433401

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.