Therapeutic nucleosides

Details Therapeutic nucleosides Therapeutic nucleosides

1989-12-22

1991-07-23

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 81, 544244, 544277, A61K 3152, C07D47318

Patent

active

050343947

ABSTRACT:
The present invention relates to 6-substituted purine carbocyclic nucleosides and their use in medical therapy particularly in the treatment of HIV and HBV infections. Also provided are pharmaceutical formulations and processes for the preparation of compounds according to the invention.

REFERENCES:
patent: 4543255 (1985-09-01), Shealy et al.
patent: 4605659 (1986-08-01), Verheyden et al.
patent: 4613666 (1986-09-01), Fukukawa et al.
patent: 4859677 (1989-08-01), Borchardt et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4931559 (1990-06-01), Vince et al.
Marquez et al., Medicinal Research Reviews, vol. 6, No. 1, pp. 1-3, 8-10, 21, 25 and 37-40 (1986).
Trost et al., J. Am. Chem. Soc., vol. 110, No. 2, pp. 621-622 (01/20/88).
Synthesis of Carbocyclic Aminonucleosides, S. Daluge & R. Vince, J. Org. Chem., vol. 43, No. 12, 1978, pp. 2311-2320.
Antiviral Research Program and Abstracts of the Second International Conference on Antiviral Research, Williamsburg, W. Va., U.S.A., 10-14, Apr. 1988, vol. 9, No. 1/2, p. 120, abstract entitled "Patent and Selective Antiviral Activity of a New Nucleoside Analog".
White et al., Biochem. Bio. Phys. Research Communication, vol. 161, No. 2, pp. 393-398, Jun. 15, 1989, Comparison of the Effect of Carbovir, AZT and etc.
Yeom et al., Antimicrobial Agents and Chemotherapy, Feb., 1989, pp. 171-175, vol. 3, No. 2, Pharmacokinetics and Bioavailability of Carbovir, a Carbocyl Nucleoside Active Against Human Immunodeficiency Virus in Rats.
Marquez et al., Nucleosides & Nucleotides, 6(1&2), 239-244, (1987), Synthesis of 2',3'-Dideoxycyclopentenyl Carbocyclic Nucleosides as Potent Drugs for the Treatment of AIDS.
Vince et al., Bio. Chem. & Bio. Phys. Res. Comm., pp. 1046-1053, vol. 15, No. 2, 1988, Potent and Selective Activity of a New Carbocyclic Nucleoside Analog (Carbovir: NSC 614846) Against Human Immunod. Virus in Vitro.
Rory P. Remmel, Journal of Chromatography, 489, (1989), pp. 323-331, Liquid Chromatographic Assay of Carbovir, a Carbocyclic Nucleoside Active Against Human Immunodeficiency Virus.
Koppel et al., Potential Purine Antagonists. XIII, Oct., 1958, pp. 1457-1460, Potential Purine Antagonists. XIII. Synthesis of Some 8-Methylpurines.sup.1.
Madhaven et al., J. Org. Chem., 1986, 51, pp. 1287-1293, A Novel and Stereospecific Synthesis of (+)-and (-)-Aristeromycin.sup.1,2.
Shuto et al., Tetrahedron Letters, vol. 28, No. 2, pp. 199-202, 1987, A Facile One-Step Synthesis of 5'-Phosphatidylnucleosides.
Kam et al., J. Org. Chem., 1981, 46, pp. 3268-3272, Carbocyclic Sugar Amines: Synthesis and Stereochemistry of Racemi.alpha.-and .beta.-Carbocyclic Ribofuranosylamine, Carbocyclic Lyxofuranosylamine, and Related Compounds.
Temple et al., J. Org. Chem., vol. 40, No. 21, 1975, p. 3141, Preparation of 2,5-Diamino-4,6-Dichloropyrimidine.sup.1.
Bruce N. Ames, Assays of Phosphate and Phosphatases, [10], pp. 115-118, Assay of Inorganic Phosphate, Total Phosphate and Phosphatases.
Paper--J. Med. Chem., 1985, pp. 1385-1386, Resolution of Aristeromycin Enantiomers.
Murray et al., J. Org. Chem., 1987, 52, pp. 746-748, Chemistry of Dioxiranes. 6. Electronic Effects in the Oxidation of Sulfides and Sulfoxides by Dimethyldioxirane.sup.1.

Affiliated with

Also associated with

Rating

Therapeutic nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic nucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-432488