Plasma gas discharge treatment for improving the compatibility o

Details Plasma gas discharge treatment for improving the compatibility o Plasma gas discharge treatment for improving the compatibility o

1989-08-21

1991-07-23

Morgenstern, Norman

Stock material or miscellaneous articles

Structurally defined web or sheet

Discontinuous or differential coating, impregnation or bond

427 2, 427 40, 427 41, 604266, 428422, 428254, 428265, B32B 2700, A01N 102, B05D 306, A61M 2500

Patent

active

050342657

ABSTRACT:
A method of treating articles to improve their biocompatibility is disclosed. A polymeric substrate material is positioned within a reactor vessel and exposed to plasma gas discharge in the presence of an atmosphere of an inert gas and then in the presence of an organic gas, such as a fluorinated hydrocarbon gas, which forms a thin, biocompatible surface covalently bonded to the surface of the substrate. The method is particularly useful in the treatment of vascular graft materials to produce grafts that are both thrombi- and emboli-resistant.

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This invention was made with government support under Grant No. HL22163 by the National Heart, Lung and Blood Institute, National Institute of Health .

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