Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Reexamination Certificate
2010-10-11
2011-12-06
Zemel, Irina S (Department: 1765)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
C525S054200, C525S398000, C525S400000, C525S437000, C525S535000, C525S539000, C514S022000, C514S023000, C514S402000, C514S404000, C514S408000
Reexamination Certificate
active
08071678
ABSTRACT:
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide.
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Fang Zhihao
Roberts Michael J.
Nektar Therapeutics
Wilson Mark A.
Zemel Irina S
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