Use of ferritin to treat iron deficiency disorders

Details Use of ferritin to treat iron deficiency disorders Use of ferritin to treat iron deficiency disorders

2008-01-29

2011-12-06

Gamett, Daniel C (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S001200, C514S017700

Reexamination Certificate

active

08071542

ABSTRACT:
The present inventors have demonstrated the presence of H-ferritin receptors on endothelial cells in culture and on rat brain rat brain microvasculature, identifying H-ferritin as a means for transporting iron across the blood brain barrier. The present invention provides a method for treating an iron deficiency disorder in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a ferritin-iron complex. In an embodiment of the invention, the ferritin-iron complex comprises H-ferritin. In another embodiment, the iron deficiency disorder comprises an iron deficiency in the brain. The present invention also provides a method for delivering iron to the brain, comprising administering iron in the form of a ferritin-iron complex to a patient, whereby said iron is transported across the blood-brain barrier and delivered to the brain; a method for using H-ferritin as a targeting moiety, comprising attaching H-ferritin to a liposome, whereby said liposome is targeted to the brain and/or cells within the brain; and a method for treating an iron overload disorder in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a multi subunit ferritin complex, wherein said multi subunit ferritin complex is at less than 100% iron binding capacity.

REFERENCES:
patent: 2004/0186048 (2004-09-01), Broyles et al.
patent: 2006/0116349 (2006-06-01), Helenek et al.
patent: 2007/0160658 (2007-07-01), Connor et al.
Fisher et al., Am J Physiol Cell Physiol 293: C641-C649, 2007.
University of Maryland Medicine web publication, “Blood Diseases: Iron Deficiency Anemia”, author unknown, published 2003, accessed from http://web.archive.org/web/20030803190356/www.umm.edu/blood/aneiron.htm Apr. 1, 2010.
Mahoney et al., “Potential of the Rat as a Model for Predicting Iron Bioavailability for Humans”, Nutrition Research, vol. 4, pp. 913-922, 1984.
Chang et al., “Recovery from iron deficiency in rats by the intake of recombinant yeast producing human H- ferritin”, Nutrition 21 (2005) 520-524.
Seo et at., “Enhanced expression and functional characterization of the human ferritin H- and L-chain genes inSaccharomyces cerevisiae”, Appl. Microbiol Biotechnol (2003) 63: 57-63.
Beard et al., “Purified Ferritin and Soybean Meal Can be Sources of Iron for Treating Iron Deficiency in Rats”, Human and Clinical Nutrition, (1995), pp. 154-160.
Roncagliolo et al. “Evidence of Altered Central Nervous System Development in Infants with Iron Deficiency Anemia at 6 mo: Delayed Maturation of Auditory Brainstem Responses”, Am. J. Clin. Nutr., 1998, vol. 68, pp. 683-690.
Hulet et al. “Oligodendrocyte Progenitor Cells Internalize Ferritin via Clathrin-Dependent Receptor Mediated Endocytosis”, J. Neurosci. Res., Jun. 200, vol. 61, pp. 52-60 (Abstract Only).

Affiliated with

Also associated with

Rating

Use of ferritin to treat iron deficiency disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of ferritin to treat iron deficiency disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of ferritin to treat iron deficiency disorders will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4310003