Chemistry: analytical and immunological testing – Including chromatography
Reexamination Certificate
2007-10-22
2011-11-22
Warden, Jill (Department: 1773)
Chemistry: analytical and immunological testing
Including chromatography
Reexamination Certificate
active
08062898
ABSTRACT:
Application of a reference mixture of natural products for systematic analysis and comparison of the properties of biphasic solvent systems in counter-current/partition chromatography. Because the reference mixture is comprised of compounds with varying polarities, functional groups, and structural features it provides a rational method for mapping the optimal resolution polarity range of a particular solvent system. The mapping of optimal resolution polarity ranges of solvent systems provided for the description of the overall optimal resolution polarity range of a solvent system family, comprised of the same solvents in different proportions. By comparing the reference mixture performance in the individual members of a solvent system family, the solvent system that best functions as the representative of, or portal to, the solvent system families is determined. Use of the reference mixture also afforded a method to compare the overall optimal resolution polarity ranges of solvent system families. Based on performance of reference mixture chromatograms, the CCC properties of solvent systems, can be compared and their CCC potential examined. The methods of the invention employing the reference mixture provides was used to identify a quaternary solvent system, hexane/t-butylmethylether/acetonitrile/water (HterAcWat), which was found to be useful for CCC of mixtures containing natural products.
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Friesen John Brent
Pauli Guido F.
Cole Monique
Greenlee Sullivan P.C.
The Board of Trustees of the University of Illinois
Warden Jill
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