Therapeutic inhibitor of vascular smooth muscle cells

Details Therapeutic inhibitor of vascular smooth muscle cells Therapeutic inhibitor of vascular smooth muscle cells

2001-07-20

2011-11-29

Vivlemore, Tracy (Department: 1635)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C514S001000

Reexamination Certificate

active

08067022

ABSTRACT:
Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent. Also discussed are mechanisms for in vivo vascular smooth muscle cell proliferation modulation, agents that impact those mechanisms and protocols for the use of those agents.

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