Method of and apparatus for predicting computed tomography contr

X-ray or gamma ray systems or devices – Specific application – Computerized tomography

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

378 95, 36441315, A61B 603

Patent

active

055839029

ABSTRACT:
A method and apparatus are disclosed for predicting prior to injection an organ specific contrast enhancement in a patient for a preselected contrast injection protocol for pre-determining a computed tomography scan. The invention is preferably implemented in a computer program which creates a mathematical model of human cardiovascular physiology in a hypothetical patient with a specific body habitus subjected to the pre-selected contrast injection protocol. The predicted contrast enhancement is then displayed for operator approval and may be then used to control a CT scanner to perform the scan with the pre-selected injection protocol. The mathematical model includes models of organs and vessels using differential equations to describe mass transport of contrast agent through the cardiovascular system.

REFERENCES:
patent: 5034987 (1991-07-01), Fujimoto et al.
patent: 5383231 (1995-01-01), Yamagishi
patent: 5459769 (1995-10-01), Brown
Dynamic Hepatic CT: How Many Years Will It Take `Til We Learn`? Walkey, M. M. Radiology, vol. 1, Oct., 1991: 181-17-24.
Investigation of Contrast Enhancement In CT Of The Liver: The Need For Improved Methods, Dodd, G. D., Baron, R. L. (commentary), AJR 1993: 160:643-646.
Contrast-Enhanced Spiral CT Of The Liver: Effect Of Different Amounts And Injection Rates Of Contrast Material On Early Contrast Enhancement. Small, W. C., Nelson, R. C., Bernardino, M. E., Brummer, L. T. AJR 1994: 163:87-92.
Cardiac Output And Regional Blood Flow, Wade O. L., Bishop, J. M. F. A. Davis Co., Philadelphia, 1962, pp. 86-95.
Cardiovascular Physiology. Milnor, W. R. Oxford University Press, Oxford, 1990, pp. 6-13; 28-39; 52-59; 328-331; 436-445.
Structure-Function Relations In The Peripheral Circulation. Best & Best & Taylor's Physiological Basis of Medical Practice, Twelfth Edition, Chapter 6, pp. 118-123; 128-130; and 142; Chapter 25, Physiology Of The Body Fluids, pp. 406-408, edited by West, J. B., Williams & Wilkins, 1991.
Circulation-Time Models Of The Uptake Of Inhaled Anaesthetics And Data For Quantifying Them. Mapleson, W. W. Brit J. Anaesth, 1973; 45:319-333.
Summary of Organ Weight (g) For Pediatric And Adult Phantoms, CRC Handbook of Medical Physics, ICRP Publication 23, 1984, pp. 428, 134-135.
Local Control Of Blood Flow By The Tissues And Nervous And Humoral Regulation, Textbook Of Medical Physiology, Chapter 20, Guyton, A. C. W B Saunders Co. 7th Ed. Philadelphia, 1986, pp. 228, 230, 340, 342, Chapter 33, Partition of The Body Fluids: Osmotic Equilibria Between Exctracellular And Intracellular Fluids, pp. 382, 384, 386, 388, 390, and 392.
Human Pharmacokinetics Of Iohexol: A New Nonionic Contrast Medium. Olsson, B. Aulie A, Sveen, K., Andrew, E. Investigative Radiology Mar.-Apr. 1983; vol. 18, 18:177-182.
Applications Of A Mathematical Model For Drug Distribution In Mammals In Chemical Engineering In Medicine And biology. Bischoff, K. B. Edited by D. Hershey, Plenum Press, NY, 1967;417-466.
Transport Phenomena In The Cardiovascular System, Middleman, S. John Wiley & Sons, Inc. NY, 1972, pp. 1-299.
Radioisotopes And Circulation, Nadler S. B., Hidalgo J. U. Little, Brown & Co., Blood Volume, Ch. 4, Boston 1965, pp. 64-71, 86-93.
Numerical Recipes. Chapter 15, Integration of Ordinary Differential Equations. Press WH, Flannery B. P., Teukolsy S. A., Vetterling W. T., Cambridge University Press, Cambridge, 1986, pp. 547-561.
Dynamic Contrast-Enhanced CT Of The Liver: Comparison Of Contrast Medium Injection Rates And Uniphasic And Biphasic Injection Protocols. Heiken J. P, Brink J. A., McClennan B. L., Sagel S. S., Forman H. P., DiCroce J. Radiology May, 1993; 187:327-331.
Dynamic Incremental CT: Effect Of Volume And Concentration of Contrast Material And Patient Weight On Hepatic Enhancement. Heiken J. P., Brink J. A., McClennan B. L., Sagel S. S., Crowe T. M., Gaines M. V. Radiology, May, 1995; 195:353-357.
Extravascular Contrast Material: The Major Component Of Contrast Enhancement. Kormano M, Dean P. B. Radiology. Nov., 1976; 121:379-382.
The Permeability Of Capillaries In Various Organs As Determined by Use Of The `Indicator Diffusion` Method. Crone, C. Acta Physiol Scand 1963; 58:292-305.
Estimation Of The Capillary Permeability Coefficients Of Inulin In Various Tissues Of The Rabbit. Wittmere L. E., Bartlett M., Johnson J. A. Microvas Res 1976; 11:67-78.
A Linear Method For Determining Liver Sinusoidal And Extravascular Volumes. Goresky C. A. American Journal Physiology. 1963;204(4):626-640.
Capillary Exchange Modeling: Barrier-Limited And Flow-Limited Distribution. Goresky C. A., Ziegler W. H., Bach G. G. Circulation Research Nov., 1970;27:739-764.
Some Mathematical Aspects Of Chemotherapy-II: The Distribution Of A Drug In The Body. Bellman R., Jacquez J. A., Kalaba R. Bull Math Biophys. 1960;22:309-322.
Respiration And Circulation, Altman P. L., Dittmer D. S. Federation of American Society of Experimental Biology, Bethesda, M. D., 1971, pp. 227, 232, 234, 320, 357, 377, 379, 383, 385, 417, 419, 424, 426, 428, 431, 433, 435, 459, 501, 503, 505, 507, 510.
Radiopapque Contrast Media Radiopharmaceuticals Enhancement Agents For Magnetic Resonance Imaging And Ultrasound. Swanson D. P., Weingarden M. Swanson D. P., Chilton H. M., Trall J. H., ed. Pharmaceuticals In Medical Imaging. Macmillan Pub. Co. NY, 1990, pp. 78-97.
Circulatory Physiology: Cardiac Output And Its Regulation. Guyton A. C. W. B. Saunders Co., Philadelphia, 1963, pp. 3-15, 154-157.
Changes In Cardiac Output With Age. Brandfonbrener M. et al. Circulation vol. 12, Oct. 1955, pp. 557-566.
Measurement Of Cardiace Output by Computed Transmission Of Tomography. Herfkens R. J., et al. Inv. Radiology Nov.-Dec., 1982, pp. 550-553.
Dynamic Contrast Enhancement Of The Upper Abdomen: Effect Of Contrast Medium And Body Weight. Kormano, M., M. D., Kaarina P., M. D., Soimakallio, S., M. D. Kivimaki, T., R. T. Investigative Radiology, vol. 18, Jul.-Aug. 1983, pp. 364-367.
Helical CT of the Liver: Clinical Application of An Automated Computer Technique SmartPrep for Obtaining Images With Optimal Contrast Enhancement; Silverman P., Roberts S., Tefft M. C., Brown B., Fox SH., Cooper C., Zeman R. AJR Jul., 1995 165:73-78.
Optimal Contrast Enhancement Of the Liver Using Helical (Spiral) CT: Value of SmartPrep. Silverman P., Brown B., Wray H., Fox S., Cooper C., Roberts S., Zeman R. AJR May, 1995; 164:1169-1171.
Technical Developments and Instrumentation. Parenchymal Liver Enhancement With Bolus-Triggered Helical CT: Preliminary Clinical Results. Kopka L., Funke M., Fischer U., Vosshenrich R., Oestmann J. W., Grabbe E. Radiology Apr., 1995, vol. 195, No. 1, pp. 282-284.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of and apparatus for predicting computed tomography contr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of and apparatus for predicting computed tomography contr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of and apparatus for predicting computed tomography contr will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-430395

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.