Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2009-04-06
2011-12-06
Loewe, Sun Jae (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S556000
Reexamination Certificate
active
08071639
ABSTRACT:
Soft anticholinergic zwitterions of the formulas:wherein R1and R2are both phenyl or one of R1and R2is phenyl and the other is cyclopentyl; and wherein each asterisk marks a chiral center; said compound having the R, S or RS stereoisomeric configuration at each chiral center unless specified otherwise, or being a mixture thereof.
REFERENCES:
patent: 2005/000815 (2005-01-01), None
patent: 2006/066928 (2006-06-01), None
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Wu, Whei-Mei et al.: “Pharmacokinetic and Pharmacodynamic Evaluations of the Zwitterionic Metabolite of a New Series ofN-Substituted Soft Anticholinergics”, Pharmaceutical Research, vol. 22, No. 12, pp. 2035-2044 Dec. 12, 2005 (available online Sep. 26, 2005), Kluwer Academic/Plenum Publishers, USA.
Banholzer, Von R. et al.: “Synthesis of anticholinergically active N-alkylnorscopolamines and their quaternary salts with particular consideration of the bronchospasmolytic compound (−)-N-ethylnorscopolamine methobromide (Ba 253 BR)”, Arzneimittel-Forschung, 35(1A), pp. 217-228, 1985, Editio Cantor, Germany.
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Buchanan & Ingersoll & Rooney PC
Loewe Sun Jae
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