Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2003-07-25
2011-10-18
Swartz, Rodney P. (Department: 1645)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S009200, C424S130100, C424S184100, C424S234100, C424S265100, C424S268100, C435S004000, C435S007100, C435S007220
Reexamination Certificate
active
08038986
ABSTRACT:
The present invention relates to a method of inducing an immune response to a parasite utilizing an immunogenic composition comprising a glycosylphosphatidylinositol (“GPI”) inositolglycan domain or its derivative or equivalent. The present invention is useful as a prophylactic and/or therapeutic treatment for microorganism infections of mammals such as parasite infections and particularly infection byPlasmodiumspecies. The invention also provides a method of monitoring, or qualitatively or quantitatively assessing an immune response to a microorganism such as a parasite. More particularly, this aspect of the present invention is directed to assessing said immune response utilizing a GPI inositoglycan domain or its derivative or equivalent, which facilitates the qualitative and/or quantitative analysis of anti-GPI antibodies in a biological sample, the identification of unique specificities of antibodies, epitope specific screening or the rational design of immunogenic molecules and the generation, thereby, of functionally effective immunointeractive molecules.
REFERENCES:
patent: 2006/0089330 (2006-04-01), Seeberger et al.
patent: 43 11 580 (1994-08-01), None
patent: WO 00/15254 (2000-03-01), None
patent: WO 00/24406 (2000-05-01), None
Naik R.S. et al., “Glycosylphosphatidylinositol Anchors ofPlasmodium falciparum: Molecular Characterization and Naturally Elicited Antibody Response that May Provide Immunity to Malaria Pathogenesis”,The Journal of Experimental Medicine 192(11):1563-1575 (2000).
Vafai A., “Boosting Immune Response with a Candidate Varicella-Zoster Virus Glycoprotein Subunit Vaccine”,Vaccine 13(14):1336-1338 (1995).
Romero G. et al., “Anti-Inositolglycan Antibodies Selectively Block Some of the Actions of Insulin in Intact BC3H1 Cells”,Proc. Natl. Acad. Sci. USA 87:1476-1480 (1990).
Schofield L. et al., “Synthetic GPI as a Candidate Anti-toxic Vaccine in a Model of Malaria”,Nature 418:785-789 (2002).
Schofiled, L, et al., “Synthetic GPI as a Candidate Anti-Toxic Vaccine in a Model of Malaria”Nature(2002) pp. 785-789, vol. 418.
Scully , Scott, Murphy & Presser, P.C.
Swartz Rodney P.
The Walter and Eliza Hall Institute of Medical Research
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