Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2005-05-12
2011-10-04
Benzion, Gary (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
Reexamination Certificate
active
08030033
ABSTRACT:
The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
REFERENCES:
patent: 2003/0073713 (2003-04-01), Schoenhard
patent: 2005/0069936 (2005-03-01), Diamond et al.
patent: WO 01/09183 (2001-02-01), None
Siddiqui et al., “Association of multidrug resistance in epilepsy with a po9lymorphism in the drug-transporter gene ABCB1,” The New England Journal of Medicine, Apr. 10, 2003, vol. 348, No. 15, pp. 1442-1448.
Uhr et al. Biol. Psychiatry, col. 54, pp. 840-846, 2003.
Lakham et al. Epilepsy and Behavior, vol. 14, pp. 78-82, 2009.
Lucentini. The Scientitist, vol. 20, p. 16, Dec. 2004.
Uhr et al. Neuron, vol. 57, pp. 203-209, Jan. 2008.
Marzolini et al., “Polymorphism in human MDR1 (P-glycoprotein): Recent advances and clinical relevance”, Clinical Pharmacology & Therapeutics, vol. 75, No. 1, Jan. 2004, pp. 13-33.
Database SNP, Online! 2001, XP002347791, retrieved from NCBI, Database accession No. ss3189005 abstract.
Roberts et al., “A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patents treated for major depression”, Pharmacogenomics Journal, vol. 2, No. 3, 2002, pp. 191-196.
Kerb et al., “ABC Drug Transporters: Hereditary Polymorphisms and Pharmacological Impact in MDR1, MRP1 and MRP2”, Pharmacogenomics, vol. 2, No. 1, Feb. 2001, pp. 51-64.
Ackenheil et al., “Differing response to antipsychotic therapy in schizophrenia: Pharmacogenomic aspects”, Dialogues in Clinical Neuroscience 2004, vol. 6, No. 1, 2004, pp. 71-77.
Zimprich et al., “Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy”, Neurology, Sep. 28, 2004, vol. 63, No. 6, Sep. 28, 2004, pp. 1087-1089.
Binder Elisabeth
Holsboer Florian
Mueller-Myhsok Bertram
Uhr Manfred
Benzion Gary
Max-Planck-Gesellschaft zur Forderung der Wissenshaften e.V.
Rothwell Figg Ernst & Manbeck P.C.
Wilder Cynthia
LandOfFree
Polymorphisms in ABCB1 associated with a lack of clinical... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polymorphisms in ABCB1 associated with a lack of clinical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymorphisms in ABCB1 associated with a lack of clinical... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4282000